Southwest is starting with eight flights every day: five to Chicago and three to Baltimore/Washington. Fifty employees were on hand for the first day of service Sunday.
CVG officials said Southwest is a game-changer for a lot of travelers.
"It opens up the Southwest network to all the Cincinnati passengers, where as they used to drive to Louisville, Lexington, Indy or Dayton to get lower fares," Director of Air Service Development Adam Kressler said.
Southwest travelers can bring two bags without paying an extra fee. They also have a reward program that the company says has no blackout dates or seat restrictions.
Kressler said there's a good chance the addition of Southwest will mean cheaper fares on other airlines out of CVG. On average, passengers are paying $178 dollars less than they were two years ago to fly out of the airport.
"Competition drives the ticket prices down, so we expect to see the ticket prices to decrease," he said.