CINCINNATI (AP) -- Wil Myers drove in five runs and Melvin Upton Jr. had a pair of two-run homers on Friday night as the San Diego Padres scored in each of the first eight innings of a 13-4 victory that spoiled the start of Cincinnati's Big Red Machine weekend.
The National League's top-scoring team in June kept at it, piling up four homers. San Diego is averaging 5.86 runs in the month.
Myers had a solo shot off Cody Reed (0-1) in the first, singled home a run and had a bases-loaded double. Adam Rosales also had a solo homer. Three of San Diego's four homers came off Cincinnati's bullpen, which has given up 57 this season, by far the most in the majors.
San Diego has won 11 of its 14 games against Cincinnati in the last three seasons.
Colin Rea (4-3) got the win by going five innings and allowing four runs, only one earned.
The Reds honored their 1976 World Series championship team on the field pregame, and players wore throwback uniforms to the days of the Big Red Machine. Pete Rose, who will be inducted into the team's Hall of Fame and have his No. 14 officially retired over the weekend, was the last player introduced.
Reds players got into the spirit of the throwback weekend. First baseman Joey Votto wore red stirrup socks like those from the Big Red Machine days. Billy Hamilton tripled and went into third base with a headfirst slide reminiscent of Rose.
By the late innings, the 40,713 fans were booing as the Padres kept scoring.
Myers' 17th homer in the first inning extended his torrid month. The first baseman has 10 homers in June, the most in a month by a Padres player since Chase Headley hit 10 during August 2012. Myers also singled home a run in the fourth and doubled with the bases loaded in the eighth. He's batting .349 in June with 28 RBIs in 22 games.
The game matched two last-place teams, and it played that way in the third inning. The Reds scored four times with the help of three walks and two errors. Jay Bruce's single with the bases loaded drove in the final two runs.
Padres: OF Jon Jay was out of the lineup for the fourth straight game. He was hit on the right forearm by a pitch on Sunday. Manager Andy Green said he'll be examined in San Diego on Monday to determine whether he needs to go on the disabled list.
Reds: Votto was back in the starting lineup. He missed two games and was limited to a pinch-hit appearance in the third game because of a stomach ailment. Votto went 0 for 3 with a pair of walks.
Padres: LH Drew Pomeranz (6-7, 3.00) is holding opponents to a .195 batting average, fourth-best in the NL. He has eight quality starts in 14 appearances.
Reds: LH Brandon Finnegan (3-5, 3.81) has allowed three earned runs or less in 12 of his 15 starts. He's been the victim of a blown save three times.