"Gone: The Forgotten Women of Ohio" premiers July 22 at 9 p.m. on Spike TV.
Watch the trailer below:
The story began in mid-may 2014, with the disappearance of Charlotte Trego, 27. She remains missing.
About six months later, Wanda Lemons vanished. She, too, hasn't been found.
Four other women -- Timberly Claytor, Shasta Himelrick, Tameka Lynch and Tiffany Sayre -- have turned up dead.
Jason McCrary was convicted of murder in Claytor's death. Himelrick's death was ruled a suicide.
Some of the women were sex workers, most had problems with drug abuse and at least three were addicted to heroin, according to ABC News. The women's lifestyle led some family members to accuse law enforcement of dragging their heels.
Emmy Award winner Joe Berlinger is directing the eight-hour Spike TV series. According to the network, "Berlinger and his crew have mounted an investigation of their own to help solve the crimes and look into the accusations of police mishandling."
"As a father of daughters of my own, I could not help but be drawn to wanting to help solve this mystery and to find out why these families felt that they were not getting the justice they deserved," he said.
It's the second national television series on the missing women of Chillicothe: Investigation Discovery aired six-part show "The Vanishing Women" last summer.