Ludlow kept Newport off the scoreboard for the second straight year.
The Panthers induced the running clock with four minutes left in the third quarter en route to a 42-0 win over the Wildcats on Friday.
Ludlow won, 34-0 in the season opener against Newport in 2015.
The Panthers open their home slate against Bracken County next week, while the Wildcats remain in Newport to take on Finneytown (Ohio).
