BOSTON (AP) -- A late Reds' rally went for naught when Grady Sizemore lined one off the Green Monster in the 12th inning to give the Boston Red Sox a 4-3 victory on Tuesday night.
"We finally got something going a little late," Reds outfielder Ryan Ludwick said. "Any time you lose a game, you think about missed opportunities."
The Reds left 10 runners on base, while Boston left 13.
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The Reds trailed 3-1 in the eighth when Joey Votto drew a one-out walk off Junichi Tazawa and Brandon Phillips doubled to put runners on second and third. Todd Frazier singled in one run, and Ludwick tied it 3-all with a sacrifice fly.
Logan Ondrusek (0-2) pitched a scoreless 11th for the Reds but lost it an inning later. David Ortiz and Mike Napoli singled before Sizemore lined one off the left-field wall.
Reds starter Homer Bailey gave up three runs on five hits in six innings. He walked five and struck out five.
Craig Breslow (1-0) pitched one inning of scoreless relief for the win.
Sizemore and Dustin Pedroia each had three hits for the Red Sox, who won for the third time in four games. Napoli drove in a pair of runs.
The Reds tried to sign Sizemore in the offseason, but the Red Sox offered him a better deal.
An All-Star with the Cleveland Indians, Sizemore missed the last two seasons while recovering from back surgery. The Red Sox brought him in as an extra outfielder, knowing the low risk would pay off big if he returned to the form that earned him MVP votes from 2005-08.
"I've got to believe that tonight gives him even further feeling like he's contributing here rather than being someone coming back from an injury," Red Sox manager John Farrell said. "Nights like tonight go a long way and continue to rebuild Grady."
"It will never get old to walk off," said Sizemore. "I was just glad I could come through."
It was the longest game between the two teams since the Red Sox won Game 6 of the 1975 World Series on Carlton Fisk's 12th-inning homer.
Cincinnati won Game 7 to take the Series. The teams also met for interleague series in 2005 and `08.
Red Sox starter Felix Doubront allowed one run on five hits, but he walked two batters in the sixth before leaving with one out and a 3-1 lead. Burke Badenhop threw one pitch to Skip Schumaker to get an inning-ending play.
NOTES: The Reds placed RF Jay Bruce on the 15-day disabled list with a torn meniscus in his left knee and selected the contract of OF Roger Bernadina from Triple-A Louisville. Bruce had arthroscopic surgery on Monday and is expected to miss about a month. ... The game marked the 99th anniversary of Babe Ruth's first of 714 career homers, on May 6, 1915. The Red Sox LHP also pitched 12 1-3 innings and took the loss in a complete game against the Yankees at the Polo Grounds. ... The Reds announced that their April 28 rainout against the Cubs will be made up as part of a day-night doubleheader on July 8. ... Red Sox DH David Ortiz played in his 2,000th career game.