Cleanthony Early and Ron Baker scored 16 points apiece and Wichita State hit a season-high 14 3-pointers, including seven straight late, to knock the top-ranked and No. 1 seeded Bulldogs out of the NCAA tournament 76-70 on Saturday.
The Shockers (28-8) advanced to the Round of 16 for the first time since 2006, while Gonzaga becomes the first top seed to be eliminated.
Gonzaga survived a scare in the second round against Southern but couldn't hold up against a fellow mid-major from Kansas whose motto is "play angry."
The Shockers face the winner of Sunday's game between La Salle and Ole Miss.
Wichita State had the Zags down 13 early. Though Gonzaga (32-3) fought back, the barrage of 3s was too much for the small school from Spokane, Wash.
Kelly Olynyk scored 26 points to lead Gonzaga, and Kevin Pangos had 19.