- Mostly cloudy
INDIANAPOLIS (AP) -- Andrew Luck handed Russell Wilson and the Seattle Seahawks their first loss of the season.
On a day, the Colts' offense struggled at times, Luck threw for 229 yards and two touchdowns and Donald Brown put the Colts ahead with a 3-yard TD run early in the fourth quarter to knock off previously unbeaten Seattle 34-28.
Luck led yet another fourth-quarter comeback, his ninth in 21 career games.
He led the Colts on a long, methodical scoring drive to open the fourth quarter, capping it with Brown's TD run and then throwing to Reggie Wayne for a 2-point conversion.
Indy then used the clock on another long drive that ended with Adam Vinatieri's 49-yard field goal.
Wilson finished 15 of 31 for 210 yards with two TDs, one interception and ran 13 times for 102 yards. Marshawn Lynch ran 17 times for 102 yards.
T.Y. Hilton had five catches for a career-high 140 yards.
For the Seahawks (4-1), it was a loss that seemed every bit as inexplicable as last week's victory in Houston.
Despite playing without three starting offensive linemen for the second straight week, Seattle dominated the first half, rushed for 218 yards and seemed to be in control for most of the game.
Seattle lost its first regular-season game since Nov. 25 at Miami, ending a nine-game winning streak.
The game featured two blocked kicks that wound up going for scores, a 73-yard TD pass from Luck to Hilton and two 2-point conversion tries by the Colts.
But Seattle was just 2 of 12 on third down conversions, played the final nine minutes without a timeout and settled for too many field goals.
It was a costly combination.
But it didn't look as if it would end this way when Seattle opened the game by driving for a field goal, a touchdown and then got a safety after a blocked punt to make it 12-0 with 4:53 left in the first.
The Colts rallied with the long TD pass to Hilton and took the lead when Delano Howell returned a blocked field goal 61 yards for a TD.
Seattle led 19-17 at the half and appeared to take control in the third quarter after settling for two quick field goals to make it 25-17.
But Luck hooked up with Hilton again, this time on a nifty 29-yard throw down the sideline to cut the deficit to 25-23 with 4:16 left in the third.
Brown gave Indy the lead for good early in the fourth, after coach Chuck Pagano won a challenge on a third-down spot that turned a fourth down into a first down.
The Colts were in control the rest of the way.
AP NFL website: WWW.PRO32.AP.ORG
Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Are you ready for some football? The 2014 Bengals full schedule is now here!
Bengals will battle Steelers down the stretch twice
Alfredo Simon pitched into the seventh inning despite erratic control, Jay Bruce drove in a run for a fifth consecutive game and the…
As baseball fans celebrated the 100 th birthday of Wrigley Field, three Reds greats must have been smiling.
Aroldis Chapman got closer to returning to the Reds Wednesday when he pitched batting practice and manager Bryan Price pronounced him in…
With the summer heat coming, many baseball fans will be reaching for their favorite brew to keep cool. However, Cincinnati Reds fans may be…
Dusting off my critic's pen —acknowledging I haven't always called them right —I highly recommend going to see the movie…
Cincinnati restaurateur Jeff Ruby is suing former Cardinals outfielder Jim Edmonds over the name of the Precinct, a restaurant he co-owns in…
Bengals quarterback Andy Dalton used to shy away from the comparisons. That's changed with his negotiations over a contract extension.
Johnny Cueto tossed his second 3-hitter against Pittsburgh in a week and became the first Red to toss consecutive complete games since 2012.